An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine (PPh3)/1,2-dibromotetrachloroethane (DBTCE) complex in excellent yields and very short time (5 min). This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh3 /DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.
Nội dung trích xuất từ tài liệu:
1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction
1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction
Số trang: 7
Loại file: pdf
Dung lượng: 327.60 KB
Lượt xem: 7
Lượt tải: 0
Thông tin tài liệu:
Tìm kiếm theo từ khóa liên quan:
Journal of Chemistry Alkyl bromides 1.2-dibromotetrachloroethane Ring-opening reaction Appel reaction Configuration inversionTài liệu có liên quan:
-
13 trang 30 0 0
-
9 trang 29 0 0
-
14 trang 24 0 0
-
Removal of Cr(VI) from wastewater through glycine assisted synthesis of TiO2
9 trang 24 0 0 -
Influence of magnetic field on properties of electrodeposited FeCo layer
5 trang 23 0 0 -
The role of diazacrown ether in the enhancement of the biological activity of silver nanoparticles
11 trang 21 0 0 -
Spectroscopic investigation of defect-state emission in CdSe quantum dots
8 trang 20 0 0 -
17 trang 19 0 0
-
20 trang 19 0 0
-
An ionic liquid/bismuth film-modified sensor for the electrochemical detection of cefixime
14 trang 19 0 0
