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Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intratumoral immune signature benefit from pembrolizumab: Results from a single-arm phase 2 trial

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A limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods: Herein, we performed comprehensive molecular characterization of immediate (D-42 to D-1) pretreatment tumor biopsy specimens from 60 patients with sorafenib-failed HCC in a single-arm prospective phase II trial of pembrolizumab.
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Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intratumoral immune signature benefit from pembrolizumab: Results from a single-arm phase 2 trial