The aim of this work was to prepare biodegradable starch aerogels as drug carriers. The effective parameters in the synthesis and the optimal values of these parameters were determined using Minitab experimental design software. Ibuprofen was selected as a model drug for the dissolution study and loaded into optimized aerogel during the last solvent exchange step. The Fourier Transform Infrared Spectroscopy (FTIR) analysis showed that ibuprofen has been successfully loaded into the aerogel matrix without any effect on the aerogel nature. The drug loading was calculated to be 29%. The isotherm of ibuprofen adsorption into aerogels matrices followed from the Freundlich isotherm.
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Mesoporous starch aerogels production as drug delivery matrices: Synthesis optimization, ibuprofen loading, and release property
Mesoporous starch aerogels production as drug delivery matrices: Synthesis optimization, ibuprofen loading, and release property
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Tìm kiếm theo từ khóa liên quan:
Journal of Chemistry Adsorption isotherm Drug release Ibuprofen optimization Potato starch aerogel Supercritical CO2Tài liệu có liên quan:
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