Prognostic effect of lncRNA SNHG7 on cancer outcome: A meta and bioinformatic analysis

New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occurrence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in various kinds of tumors. However, the small sample size was the limitation for the prognostic value of SNHG7 in clinical application.
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Prognostic effect of lncRNA SNHG7 on cancer outcome: A meta and bioinformatic analysisZhangetal. BMC Cancer (2022) 22:10https://doi.org/10.1186/s12885-021-09068-w RESEARCH Open AccessPrognostic effect oflncRNA SNHG7oncancer outcome: ameta andbioinformaticanalysisYunyuanZhang1, QingwuTian1, ShifengHuang2, QingWang1, HongmeiWu3, QianDong4,5,6*†andXianChen1*†  Abstract  Background:  New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occur- rence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in vari- ous kinds of tumors. However, the small sample size was the limitation for the prognostic value of SNHG7 in clinical application. The aim of the present meta-analysis was to conduct a qualitative analysis to explore the prognostic value of SNHG7 in various cancers. Methods:  Articles related to the SNHG7 as a prognostic biomarker for cancer patients, were comprehensive searched in several electronic databases. The enrolled articles were qualified via the preferred reporting items for systematic reviews and meta-analysis of observational studies in epidemiology checklists. Additionally, an online database based on The Cancer Genome Atlas (TCGA) was further used to validate our results. Results:  We analyzed 2418 cancer patients that met the specified criteria. The present research indicated that an elevated SNHG7 expression level was significantly associated with unfavorable overall survival (OS) (HR = 2.45, 95% CI: 2.12–2.85, p Zhangetal. BMC Cancer (2022) 22:10 Page 2 of 13 Keywords:  Cancer, SNHG7, meta-analysis, prognostic biomarkerBackground tumors. However, the small sample size was the limita-With the increasing prevalence of cancer, carcinomas had tion for the prognostic value of SNHG7 in clinical appli-gradually been recognized as a major threaten to human cation. In the present study, a qualitative meta-analysishealth the world over [1, 2]. Although great progresses was conducted to explore the prognostic effect of SNHG7continued to be made in cancer treatment, it is not sat- on cancer patients.isfactory because the long-term survival rate of manycancers is still remaining very low. With the rapid devel- Methodsopments of science and technology, researchers gradually Literature search andselectionrealize that the molecular mechanisms of tumorigenesis 0th, 2020, which Articles published in English up to Dec 3and development are still need further elucidated. There- related to the lncRNA SNHG7 as a prognostic biomarkerfore, there is an urgent need to find new and effective for cancer patients, were comprehensive searched inclinical biomarkers for early diagnosis, prognosis and several electronic databases. These databases include:ideal therapeutic targets for cancer patients. Long non- Springer, Cochrane Library, Embase, BioMed Central,coding RNAs (lncRNAs) have a wide range of biological PubMed, Science Direct and ISI Web of Knowledge. Arti-functions, such as alternative splicing, chromatin modi- cles with the following keywords for the online searchfication, dosage compensation, inactivation of major were included: (“SNHG7” OR “small nuclear RNA hosttumor suppressor genes and gene imprinting etc [3–5]. gene 7” OR “lnc RNA-” OR “long noncoding RNA-” OR As a modulator of biological processes, small nucleolus “noncoding RNA-”) AND (“neoplasm” OR “tumor” ORRNA host gene 7 (SNHG7) that located on chromosome “cancer” OR “carcinoma”) AND (“metastasis” OR “prog-9q34.3, has been firstly discovered in lymphoblastoid nosis” OR “metastatic” OR “prognostic”). Manuallycell lines. New evidence from clinical and fundamental searched of the reference lists were also conducted toresearches suggests that lncRNA SNHG7 is expressed in obtain potential eligible studies.many tissues and involved in the occurrence and develop-ment of various carcinomas. Researches have suggested Inclusion andexclusion criteriathat SNHG7 may associated with methylation. For exam- Inclusion criteria: 1) definite diagnosis or histopathol-ple, Wu et al. had discovered that upregulated DNMT1 ogy confirmed for carcinomas;2) studies investigating thecould induce hypermethylation of the SNHG7 promotor prognostic values of lncRNA SNHG7 in various cancers;in hypopharyngeal cancer cells [6]. It was also reported 3) suffic ...